Napa Rapid

Pharmacology

Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.

Paracetamol (Acetaminophen) is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme’s active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. The antipyretic properties of acetaminophen are likely due 

Dosage & Administration
Tablet:

• Adult: 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily.
• Children (6-12 years): ½ to 1 tablet 3 to 4 times daily. For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day.

Extended Release Tablet:

• Adults & Children over 12 years: Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours).The tablet must not be crushed.

Syrup/Suspension:

• Children under 3 months: 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily.
• 3 months to below 1 year: ½ to 1 teaspoonful 3 to 4 times daily.
• 1-5 years: 1 -2 teaspoonful 3 to 4 times daily.
• 6-12 years: 2-A teaspoonful 3 to 4 times daily.
• Adults: 4-8 teaspoonful 3 to 4 times daily.

Suppository:

• Children 3-12 months: 60-120 mg,4 times daily.
• Children 1-5 years: 125-250 mg 4 times daily.
• Children 6-12 years: 250-500 mg 4 times daily.
• Adults & children over 12 years: 0.5-1 gm 4 times daily.

Paediatric Drop:

• Children Upto 3 months: 0.5 ml (40 mg)
• 4 to 11 months: 1.0 ml (80 mg)
• 7 to 2 years: 1.5 ml (120 mg). Do not exceed more than 5 dose daily for a maximum of 5 days.

Tablet with actizorb technology: It dissolves up to five times faster than standard Paracetamol tablets. It is a fast acting and safe analgesic with marked antipyretic property. It is specially suitable for patients who, for any reason, can not tolerate aspirin or other analgesics.

• Adults and children (aged 12 years and over): Take 1 to 2 Tablets every four to six hours as needed. Do not take more than 8 caplets in 24 hours.
• Children (7 to 11 years): Take ½-1 Tablet every four to six hours as needed. Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years.

IV Infusion:

Children >2 to 12 years of age: the recommended dosage of Paracetamol IV is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Paracetamol IV of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Paracetamol of 75 mg/kg per day.

Adults and adolescents weighing 50 kg and over: the recommended dosage of Paracetamol IV is 1000 mg every 6 hours or 650 mg every 4 hours, with a maximum single dose of Paracetamol IV of 1000 mg, a minimum dosing interval of 4 hours, and a maximum daily dose of Paracetamol of 4000 mg per day.

Adults and adolescents weighing under 50 kg: the recommended dosage of Paracetamol IV is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Paracetamol IV of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Paracetamol of 75 mg/kg per day.

Side Effects

Side effects of Napa Rapid (Actizorb) are usually mild, though haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.

Common Questions about Napa Rapid (Actizorb) 500 mg Tablet
What is Napa Rapid (Actizorb) 500 mg Tablet?

Napa Rapid (Actizorb) 500 mg Tablet is a medication that performs its action by obstructing the release of pain and fever chemical messengers.

What are the uses of Napa Rapid (Actizorb) 500 mg Tablet?

Napa Rapid (Actizorb) 500 mg Tablet is used for the treatment and prevention of conditions and symptoms of diseases like Post immunization pyrexia, menstrual cramps and fever.

What are the Side Effects of Napa Rapid (Actizorb) 500 mg Tablet Napa Rapid (Actizorb) 500 mg Tablet?

Allergic reaction, gastric ulcers, fatigue, anemia, nausea and vomiting are possible side effects.

What are the instructions for storage and disposal Napa Rapid (Actizorb) 500 mg Tablet?

Napa Rapid (Actizorb) 500 mg Tablet should be stored at room temperature, away from heat and direct light. Keep it away from the reach of children and pets.

Should I use Napa Rapid (Actizorb) 500 mg Tablet empty stomach, before food or after food?

If you take Napa Rapid (Actizorb) 500 mg Tablet with the food, the reactions that took place in the body carry-outs in a much effective manner.

How long do I need to use Napa Rapid (Actizorb) 500 mg Tablet before I see improvement in my conditions?

Napa Rapid (Actizorb) 500 mg Tablet should be consumed, until the complete eradication of the disease. It is advised to use, till the time directed by your doctor.

Is there any food or drink I need to avoid while taking Napa Rapid (Actizorb) 500 mg Tablet?

You can follow your normal diet under the usage of Napa Rapid (Actizorb) 500 mg Tablet.

Will Napa Rapid (Actizorb) 500 mg Tablet be more effective if taken in more than the recommended dose?

There is no need to take Napa Rapid (Actizorb) 500 mg Tablet more than its recommended doses.

Can I take other medications along with Napa Rapid (Actizorb) 500 mg Tablet?

Do not use any OTC for cough, cold, allergy, or pain medication without consulting your doctor or pharmacist. Napa Rapid (Actizorb) 500 mg Tablet contains many combination of medicines. If you use certain products together you may accidentally use too much of Napa Rapid (Actizorb) 500 mg Tablet.

Can I take Napa Rapid (Actizorb) 500 mg Tablet with antibiotics?

There are hundreds of antibiotics used to treat infections, so once you receive your prescription, ask your doctor or pharmacist if you can also take Napa Rapid (Actizorb) 500 mg Tablet at the same time that you take the antibiotic.

Is Napa Rapid (Actizorb) 500 mg Tablet an NSAID drug?

No, Napa Rapid (Actizorb) 500 mg Tablet is not classified as an NSAID (nonsteroidal anti-inflammatory drug). It is classified as a miscellaneous analgesic for mild to moderate pain and fever.